Why Work With Us
We have built an automated synthesis platform because the Make step shouldn't be the bottleneck in DMTA cycles. Here's what that means in practice.
Timelines
Our median lead time is under 10 business days, with the fastest orders being shipped within 5 days. This timeline covers sourcing of building blocks, synthesis, purification, and QC.
| Metric | onepot CORE | Typical enumerated space |
|---|---|---|
| The shortest lead time | 5 business days | 3–4 weeks |
| Median lead time | <10 business days | 4–5 weeks |
| Customs clearance | None (US-based) | 1 week |
We operate entirely in the United States. Building blocks come from US-based suppliers with validated performance. Compounds are shipped domestically.
The Space
onepot CORE contains 3.4 billion compounds derived from seven reaction classes and 320,108 building blocks. The CORE has minimal overlap with existing libraries. For example, overlap with Enamine REAL is only 4.7%, so you are accessing genuinely novel chemical matter. Approximately 73% of compounds are Ro5-compliant.
Current reaction classes:
Additional reactions can be added on request. Ugi reactions are coming soon.
Synthetic Feasibility
We rely not only on manual filters and functional group exclusion rules. Our ML models, guided by Phil — our AI chemist — are trained on internal synthesis data.
The models predict actual success probability for your specific combination of substrates, not just template matching. This means that we can take on compounds that would be filtered out by conservative rule-based systems, while avoiding confident predictions on reactions that will not work.
What you get with each compound
Every compound ships with LC/MS data confirming identity and purity (UV trace at 254 nm, single-quad MS). We report explicit confidence levels and, when multiple routes exist, pick those based on predicted success rate and availability of reagents.
Case Studies
Initial order was for 51 compounds. 20 compounds were ready in 3 business days, 40 — within 7 days; the full order was completed by day 12. 80% of compounds met high purity threshold (over 95%).
The customer returned and has since quoted over 1,000 compounds in total.
| Business days | Compounds ready |
|---|---|
| 3 | 20 |
| 6 | 28 |
| 7 | 40 |
| 12 | 51 |
Customer provided a target molecule requiring chemistry outside of our initial reaction set. We added two new reactions and developed a multi-step workflow to generate synthesizable analogs of the target molecule. 28 compounds were selected and successfully delivered.
This engagement expanded our platform capabilities for subsequent users.
Figure 1: Enumeration approach
We performed a custom library enumeration around a proprietary scaffold with a covalent warhead. 30 compounds were synthesized and shipped in 5 business days. Average purity was 97%.
Purity distribution: majority of compounds, >95%, small fraction in a 85–90% range.
Validation
We have validated identity and assay-readiness of synthesized compounds through independent testing:
NMR Confirmation
24 randomly selected synthesized compounds were verified by ¹H NMR (400 MHz, DMSO-d₆). All spectra consistent with expected structures.
Figure 2: NMR validation of synthesized compounds
Biological Assay Validation
We synthesized and tested a DPP4 inhibitor series. IC₅₀ values for synthesized standards matched commercial references.
Purity Confirmation
NMR-derived purity estimates were aligned with LC/MS data. Residual starting materials and process impurities are documented if present.
Limitations
We are transparent about what we are not able to do yet. Thus, (a) multi-step sequences (beyond two steps) are performed case-by-case; (b) air-sensitive chemistry requires discussion; (c) some reaction classes (photochemistry, electrochemistry) are on the roadmap but not available today; (d) if a building block is not in the US supplier catalogs, this will increase the sourcing time and the lead time in general.
If your project pushes beyond our current capabilities, we will tell you upfront rather than overpromise.
Pricing
Compounds from the CORE start at $125 depending on chemical risk and availability of reagents. Custom enumeration and reaction development are scoped separately.
Get in Touch
We can discuss your project, run feasibility checks, or answer technical questions.