CORE (Compounds On-demand via Robotic Execution) is an enumerated chemical space. We construct CORE by selecting reactions widely used in medicinal chemistry, sourcing building blocks from supplier catalogs with real-time availability, and applying ML-based feasibility scoring so the space reflects what actually works under our protocols — not just what matches a template on paper.

When you select a compound, our AI chemist Phil evaluates available routes, sources missing building blocks, determines optimal conditions, and runs reactions on automated hardware. After reaction and workup, crude product is purified by semi-prep HPLC with mass-based fraction collection, then reanalyzed by LC/MS. Compounds ship as dry solid in barcoded vials or as plated DMSO solutions.